![]() ![]() Why should Sponsors and CROs undertake data blinding in clinical trials?ĭata blinding enables Sponsors/CROs to use third-party assessors to get an independent, non-biased review of their data. ![]() Triple-blind or triple-masked studies extend the blinding to the data analysts, so the participant, clinicians/data collectors, and outcome adjudicators/data analysts are all unaware of the treatment the participant has received.Double-blind or double-masked studies where both the research team and participants do not know which participant is assigned to which treatment group.Single-blind or single-masked studies are where the participants are unaware of which treatment group they are in, but the research team knows.The different types of study blinding, include: The clinical staff administering the treatment.A blind trial is the opposite of an open, open-label, or un-blinded trial where all parties are aware of the treatment the participant receives.Īll of the different parties involved in a clinical trial are possible sources of bias and can be blinded to ensure trial objectivity, including: For example, in a blinded trial that has a group of subjects receiving the treatment being tested and a group of subjects receiving a placebo treatment, the participants would not know if they were receiving the treatment or the placebo. ![]() Blinding is used in Clinical Trials to remove any bias that can be caused intentionally or unintentionally if participants or the research team are aware of who is receiving an active or placebo treatment. ![]()
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